166 This observation led to the proposal that HBOT might be beneficial in the treatment of vascular-related headaches refractory to traditional pharmacological therapy. HBOT may be effective via its effect on several aspects of migraine pathogenesis, via activity ERK inhibitor as a serotonergic agonist and an immunomodulator of response to substance P.167,168 In addition, the role of HBOT
in moderating inflammatory pathways may be useful in targeting migraine, both as acute and preventative treatment.169,170 Practical limitations of HBOT include the requirement of a compression chamber and potential adverse effects such as pressure-related damage to the ears, sinuses, and lungs, temporary worsening of myopia, claustrophobia and oxygen poisoning.171 A recent Cochrane Review171 assessing the safety and effectiveness of HBOT and normobaric oxygen therapy (NBOT) in the Selleck Peptide 17 treatment and prevention of migraine and cluster headaches found only 9 small randomized trials, with a total of 201 participants. Five trials compared HBOT with sham therapy for acute migraine treatment, 2 compared HBOT to sham therapy for cluster headache, and 2 assessed NBOT for cluster headache. Although there was some evidence suggesting that HBOT was effective in acute migraine treatment as compared to sham therapy, there was no evidence that it was useful in preventing migraine or reducing the incidence of nausea, vomiting, or the need for rescue medication.
The use of NBOT in the termination of cluster headaches was supported only by weak evidence from 2 small randomized trials, but given the safety and ease of treatment, the use of NBOT will likely continue. There is insufficient evidence from randomized trials to establish whether HBOT is
effective in the acute treatment of cluster headache. Lastly, there was no evidence to suggest that either NBOT or HBOT were effective in the prevention of either migraine or cluster headaches. There is a growing role for CAM treatment in the multidisciplinary management of headache disorders. In addition to their potential in decreasing headache frequency and intensity, these modalities also serve to provide the patient with a greater sense of self-efficacy. However, despite the supporting evidence discussed selleck in this review, there is still much to be learned about these therapeutic options and how they influence the course and outcome of headache disorders. Future research should focus on extending the current evidence base using updated standards and more rigorous methodology, and identifying which patients would be responsive to such approaches. “
“(Headache 2010;50:314-322) Arachnoid cysts represent a common, innocent, finding in routine neuroimaging of headache patients. We present the first report of symptomatic migraine with aura caused by the spontaneous rupture of a middle fossa arachnoid cyst into the subdural space. Brain imaging enabled an accurate diagnosis and, subsequently, adequate surgical management.