Introduction: Current guidelines for relapsing-remitting ms (RRMS) demand treatment with disease-modifying therapies (DMTs) at the start of the condition to avoid relapses and accumulation of neurologic impairment and disability. However, patients taking certain dental DMTs can experience gastrointestinal (GI)-related adverse occasions (AEs), particularly at dose titration. We conducted qualitative research with medical professionals (HCPs) and patients in Canada to contextualize their encounters with three dental DMTs: dimethyl fumarate (Tecfidera?), fingolimod (Gilenya?), and teriflunomide (Aubagio?). The objectives of the study would (1) gather qualitative data to higher comprehend the patient and HCP experience with GI AEs in dental MS DMT treatment in Canada and (2) determine how much two patient-reported outcome (PRO) instruments utilized in recent dental DMT trials capture the most important thing to patients regarding GI AEs in dental MS DMT treatment (content validity) and also to provide qualitative data to assist interpret PRO scores.
Methods: It was a qualitative, non-interventional, descriptive, mix-sectional study comprising HCP and patient interviews conducted in British and French, utilizing a 1:1 semi-structured interview approach.
Results: Patients reported 16 unique GI AE concepts associated with dental DMTs. Probably the most generally reported signs and symptoms were diarrhea, indigestion, and nausea. While patients acknowledged the negative impact connected with GI-related AEs, most characterised the therapy experience as positive, concentrating on preference for dental administration, perceived effectiveness of DMTs when it comes to insufficient MS relapses, slowed advancement of their disease, and improvement in MS signs and symptoms. Results supported the information validity (relevance, Diroximelcomprehension, and comprehensiveness) of these two PROs assessed. HCP feedback reinforced patient perspectives on GI concepts and also the two PRO instruments.