We studied the propofol requirement after intrathecal administration of clonidine or fentanyl in infants undergoing lower abdominal surgeries.
Sixty-five ASA I infants undergoing elective lower abdominal surgery under spinal anesthesia were assigned into four groups in this prospective randomized double-blinded study. Group B received bupivacaine based on body weight (< 5 kg = 0.5 mg center dot kg-1; 5-10 kg = 0.4 mg center dot kg-1). Group BC received 1 mu g center dot kg-1 of clonidine with bupivacaine, group BF received 1 mu g center dot kg-1 of fentanyl with bupivacaine,
and patients in group BCF received 1 mu g center dot kg-1 each of clonidine and fentanyl with bupivacaine. A bolus of 2-3 mg center dot kg-1 of propofol bolus was administered for Selleck FDA-approved Drug Library lumbar puncture. Sedation was assessed using a six-point sedation score (0-5) and a five-point reactivity score (0-4) which was based on a behavioral score. After achieving
a sedation and reactivity score of 3-4, the patients were placed lateral in knee chest position and lumbar puncture performed and test drug administered. Further intraoperative sedation was maintained with an infusion of 25-50 mu g center dot kg-1 center dot min-1 of propofol infusion.
The mean Belnacasan inhibitor +/- sd infusion requirement of propofol decreased from 35.5 +/- 4.5 in group B to 33.4 +/- 5.4 mu g center dot kg-1 center dot min-1 in group BF and further decreased to 16.7 +/- 6.2 mu g center dot kg-1 center dot min-1 and 14.8 +/- 4.9 mu g center dot kg-1 center dot min-1 in group BC and BCF, respectively. There were no statistically significant differences between BC and BCF groups. The mean sedation and reactivity scores were higher in groups BC and BCF when compared to groups B and BF.
Our study show that the requirement of www.selleckchem.com/screening-libraries.html propofol sedation reduces with intrathecal adjuvants. The reduction was significant with the addition of clonidine and clonidine-fentanyl combination as opposed
to bupivacaine alone or with fentanyl. There was no significant difference in propofol infusion requirement with the use of bupivacaine alone or with fentanyl.”
“P>Background and objectives:
The primary objective of this study was to assess the success rate of ultrasound-guided sciatic needle placement regardless of the motor stimulation in infants and toddlers.
Forty-five consecutive patients aged 7 months-2 years, scheduled for foot surgery, were included in this prospective, descriptive and blinded study. After induction of general anesthesia, sciatic nerve block was performed under ultrasound guidance in the subgluteal area using an insulated needle connected to a nerve stimulator, with the power off. At the precise point when it was presumed that the needle was touching the sciatic nerve, the peripheral nerve stimulator was turned on at 0.