Quigg, MS, Mayo Clinic, Rochester, MN; Tom D. Thacher, MD, Mayo Clinic, Rochester, MN BACKGROUND: The USPSTF recommends osteoporosis screening with DEXA in women <65 years old, whose fracture risk is equal to or greater than that of a 65 year Palbociclib clinical trial old Caucasian woman with no additional risk factors. The FRAX tool estimates that a 65 year old Caucasian woman with no other risk factors will have a 9.3 % 10-year risk for any osteoporotic

fracture. However, DEXA screening has been identified as one of the top five primary care PF-02341066 concentration clinical activities that may be inappropriately overused. We evaluated the extent of inappropriate DEXA screening for osteoporosis in our primary care setting, based on the USPSTF criteria. METHODS: Data were abstracted from all Mayo Clinic Employee and Community Health (primary care) female patients, aged 50–64 years, who underwent DEXA between March and August 2012. This data included the demographic and clinical information to calculate fracture risk with FRAX. A calculated fracture risk of 9.3 % or greater or a prior diagnosis of osteoporosis, osteopenia, hyperparathyroidism, celiac disease, or gastric bypass surgery were considered appropriate DEXA indications. RESULTS: A total of 465 women (mean age 57.4 years) Etomoxir were evaluated; with 53.1 % Family Medicine and 46.9 % Internal

Medicine patients. Consultant, midlevel, and resident providers ordered 69.9 %, 21.9 %, and 8.2 % of the DEXAs, respectively. The proportions of women with a DEXA T-score of 2.5 or less (osteoporosis) at the femoral neck and lumbar spine were 11 % and 22 %, respectively. By our criteria, 76.3 % of the DEXA tests were appropriately ordered, and 23.7 % were inappropriate. The mean age of women with inappropriate DEXA (55.4 y) was significantly lower than that of women with an appropriate DEXA (58.0 y, P < 0.001). The proportion DNA ligase of inappropriate DEXA scans was greater in women who had

never had a previous DEXA (52 %) than in those with a prior DEXA (11 %, P < 0.001). Provider type, primary care specialty, practice site, and BMI were not significantly associated with inappropriate DEXA utilization. The sensitivities of a calculated fracture risk of 9.3 % or greater for detecting osteoporosis of the femoral neck and lumbar spine were 53 % and 44 %, respectively. The corresponding specificities for femoral neck and lumbar spine were 67 % and 69 %, respectively. CONCLUSION: Approximately one quarter of the DEXA tests ordered in women aged 50–64 years were inappropriate, based on USPSTF guidelines. The USPSTF-recommended fracture risk threshold of 9.3 % for osteoporosis screening may be overly conservative, and a lower risk threshold or an alternative decision tool could increase the detection of osteoporosis in this population. FRAX was developed to predict fracture risk and not to identify those with osteoporosis by DEXA.