Conclusion. Caution should be exercised with rh-BMP-2 use in posterior cervical applications when a laminectomy has been performed. The safe and effective dose and technique for application have yet to be determined. Seroma formation is possible, which can cause acute stenosis with cord compression and neurologic compromise.”
“In view of the good skin tolerability, glycofurol was used as a vehicle-based gel, and its effect in the topical penetration of Naproxen (NAP) was investigated.
The aims of this study were to develop a suitable gel with bioadhesive property, spreadability, and viscosity for topical anti-inflammatory effect. Three gelling and adhesive agents were examined: Carbopol Belnacasan 974P, Gantrez AN 119, and polyvinylpyrollidone K30. Skin permeation rates and lag times of NAP were evaluated using the Franz-type diffusion cell in order to optimize the gel formulation. The permeation rate of NAP-based gel across
the excised rat skin was investigated. A significant increase in permeability parameters such as steady-state flux (J(ss)), permeability coefficient (K(p)), and penetration index (PI) was observed in optimized formulation containing 2% Transcutol as an permeation enhancer. From skin irritation test, it was concluded that the optimized novel glycofurol-based gel formulation was safe to be used for topical drug delivery. The developed glycofurol-based gel appeared promising for dermal and transdermal delivery of naproxen and could be applicable with water-insoluble GSK690693 drugs, which would circumvent most of the problems associated with drug therapy.”
“Study Design. Case reports.
Objective. A novel spinopelvic instrumentation system is introduced.
Summary of Background Data. Spinopelvic stabilization is Etomoxir price a problematic area of the spine.
A mobile segment (spine) is fixed onto a stabile construction (pelvis). Another problem is the spinal anatomy because L5 vertebrae are affected by shear forces due to lomber lordosis so that stabilization needs extra power and 360 degrees fusion of L5-S1 level. Long instrumentation is preferred to decrease the stress on the screws and the rods. We designed iliac plates to support lumbopelvic instrumentation laterally. Four cases of spinopelvic pathology were treated in this way manner. The short-term results are good.
Methods. Four adult cases that had spinopelvic instability were treated with a novel spinopelvic instrument. All cases were evaluated with visual analog scale (VAS), Oswestry and radiologic studies pre- and postsurgery at 6 and 12 months.
Results. All the patients benefited from the stabilization. Preoperative mean VAS scores of all patients decreased from 7.75 to 1.75 and preoperative Oswestry disability index scores decreased from 83.50 to 24.50 at the 12 months postoperative evaluation.
Conclusion. In this study, we define four cases and report that iliac wings can be used to augment stabilization.