32, 34, 35 We previously reported36 5-Fluoracil cell line that more than 15% of small HCC nodules (1-3 cm) lack the typical contrast HCC pattern at imaging (hyperenhancement in the arterial phase followed by washout),1, 2 and these theoretically correspond

to nodules in which vascular derangement has not yet fully taken place; thus, the potential of TACE is limited. In light of these considerations, our finding that the smaller nodules in the present series were less efficiently treated by arterial chemoembolization than the larger ones is not unexpected. Furthermore, Alba and coworkers12 reported that tumors that were preoperatively detected by CT because of hypervascularity had more necrosis (mean = 67.8%) and were larger (2.58 cm) than those not detected preoperatively (mean necrosis level = 1.57%, diameter = 1.68 cm). Riaz and coworkers28 found instead that the highest rate of complete necrosis after TACE could be achieved in nodules in the intermediate size range of 3 to 5 cm in comparison with smaller and larger nodules. Our population and consequent findings are different from those patients undergoing TACE as a unique modality (usually

with HCCs at an intermediate stage) and their findings. These patients often have nodules > 5 cm and rarely have tumors < 2 cm; in this case, an increase in the rate buy Ceritinib of necrosis in the larger ones would be completely unexpected. Our multivariate logistic regression analysis showed that the independent predictors of complete tumor necrosis were the selective/superselective TACE procedure (P = 0.049) and a single nodule treatment (P = 0.008), whereas the nodule size played a minor role (P = 0.089). In the setting of a locoregional bridge treatment for LT, the rate of complete necrosis according to a pathological analysis after percutaneous radiofrequency ablation was reported to be approximately 50%, but it was 61% to 63% in nodules < 3 cm and 15% in HCCs > 3 cm (usually 3-5 cm).37 The rate of complete necrosis in the entire series was fully

comparable to that achieved after selective/superselective TACE in our present population of transplant patients (53.8%). These data, together with our finding clonidine that HCCs 3 to 5 cm in size had a higher rate of necrosis than smaller tumors after TACE, support the strategy (commonly used in many centers) of using a bridge treatment involving percutaneous ablation for smaller nodules (<3 cm) and selective/superselective TACE for larger nodules (>3 cm). Combined treatment might also be an option. As for the post-TACE CT assessment, dense Lipidol uptake proved to be a poorly specific marker of a complete histological response. Dedicated trials are warranted to identify the best strategy for post-TACE evaluations.