We also thank Prof. Dr Rolf Kleber (Utrecht University) and Prof. Dr Onno van der Hart (Utrecht University) who provided advice with respect to our type 2 diabetes conceptualisation of psychological trauma and the importance of peritraumatic dissociation for inclusion in the questionnaire.
Cervical cancer (cervix uteri (CVX), corpus uteri (CRP), not otherwise specified (NOS) uterus cancer and other very rare uterus cancer (OTH) mortality data were extracted from the WHO mortality database together with population data for Belgium and the Netherlands. Different ICD (International Classification of Diseases) were used over time for death cause certification. In the Netherlands, the proportion of not-otherwise specified uterine cancer deaths was small over large periods and therefore internal reallocation could be used to estimate the corrected rates cervical cancer mortality.

In Belgium, the proportion of improperly defined uterus deaths was high. Therefore, the age-specific proportions of uterus cancer deaths that are probably of cervical origin for the Netherlands was Inhibitors,Modulators,Libraries applied to Belgian uterus cancer deaths to estimate the corrected number of cervix cancer deaths (corCVX). A Bayesian loglinear Poisson-regression model was performed to disentangle the separate effects of age, period and cohort. Results The corrected age standardized mortality rate (ASMR) decreased regularly from 9.2/100 000 in the mid 1950s to 2.5/100,000 in the late 1990s. Inclusion of age, period and cohort into the models were required to obtain an adequate fit.

Cervical cancer mortality increases with age, declines over Inhibitors,Modulators,Libraries calendar period and varied irregularly by cohort. Conclusion Mortality increased with ageing and declined over time in most age-groups, but varied irregularly by birth cohort. In global, with some discrete exceptions, Inhibitors,Modulators,Libraries mortality decreased for successive generations up to the cohorts born in the 1930s. This decline stopped for cohorts born in the 1940s and thereafter. For the youngest cohorts, even a tendency of increasing risk of dying from cervical cancer could be observed, Inhibitors,Modulators,Libraries reflecting increased Inhibitors,Modulators,Libraries exposure to risk factors. The fact that this increase was limited for the youngest cohorts could be explained as an effect of screening. Bayesian modeling provided similar results compared to previously used classical Poisson models.

However, Bayesian models are more robust for estimating rates when data are sparse (youngest age groups, most recent cohorts) and can be used to for predicting future trends. Keywords: Cervical cancer, trend analysis, mortality, Bayesian analysis, AV-951 age-cohort-period modelling Introduction Previous trend analyses on cervical cancer mortality in Belgium, including a tentative solution for the ‘not otherwise specified’ (NOS) uterine cancers certification problem, have shown a 50% decline over the past 4 decades [1].