The precipitate was filtered washed with water and crystallized from hexane. IR: νmax: 3110, 1710 cm−1, 1H NMR: δ 2.4 (s, 3H, Ar–CH3), 4.0 (s, 3H, –OCH3), 2.4 (s, 3H, isoxazole–CH3), 7.4 (d, J = 8.1 Hz, 2H,

Ar.H), 7.6 (d, J = 7.8 Hz, 2H, Ar.H), EI mass (m/z) learn more 231 (M+), 131. To a mixture of DiBAL-H (0.37 g, 0.012 mol) and ester 7(0.02 in dry THF (5 ml)) was added a solution of aluminium chloride (0.55 g, 0.004 ml) in dry THF (5 ml) slowly at 0 °C under stirring. The reaction mixture was further stirred for 1 h and heated to reflux for 1.5 h and the progress of the reaction was monitored by TLC. After the completion of the reaction the mixture was poured on to HCl ice mixture. The separated white precipitate filtered

washed with water and the solid was recrystalised with mixture of chloromethane and hexane (1.5 ratio) to obtain the respective alcohol derivatives. IR: νmax: 3460, 1513 cm−1 .1H NMR δ: 2.3 (s, 3H, Ar–CH3), 2.4 (s, 3H, Ar–CH3), 2.5 (brs, 1H, –OH, D2O exchangeable), 4.8 (s, 2H, CH2OH), 7.3 (d, J = 8.0 Hz, GS-1101 in vivo 2H, Ar.H), 7.7 (d, J = 7.8 Hz, 2H, Ar.H), EI mass (m/z) 203 (M+), 140. To a solution of alcohol 9 (0.031 mol) in heptane, thionyl chloride (4.4 g, 0.031 mol) was added drop wise over a period of 15 min at 65–700 C. The reaction mixture was heated to reflux for 2 h and the progress of the reaction monitored by TLC (hexane, EtOAc, 70, 30). After the completion of the reaction of the solvent was removed and the thionyl chloride was destroyed by adding cold water and the product was extracted with dichloromethane. Dichloromethane

solution was dried over Na2SO4, concentrated to get chloride. IR: νmax: 2923, 2864, 1450 cm−1, 1H NMR (δ ppm, CDCl3): δ 2.4 (s, 3H, –CH3), 4.4 (s, 2H, –CH2Cl), 2.3 (s, 3H, isoxazole–CH3), 7.3 (d, J = 7.7 Hz, 2H, Ar.H), 7.6 (d, J = 7.9 Hz, 2H, Ar.H), why EI mass (m/z) 221 (M+), 132, 115. A mixture of isoxazolyl methyl chloride, 9 (0.002 mol), 2-nitro imine imidazole, (0.68 g, 0.005 mol), and K2CO3 (0.36 g, 0.002 mol) in CH3CN (20 ml) was refluxed for 2–4 h. Progress of the reaction was monitored by TLC (hexane, EtOAc, 70:30), after completion of the reaction acetonitrite was removed to obtain a crude product. The crude was washed with water and filtered under suction. The solid was recrystallised from methanol to obtain pure compounds 6a–k. Isoxazole derivatives exhibit potent biological activities,12, 13 and 14 some of the reports available on the physiological activities of isoxazole heterocycles have been summarized below. We had studied the fungicidal activity of compounds 6a–k. Basis on the mode of action fungicides are classified as systemic and nonsystemic fungicides.