The important management topics are discussed in this review, and the use of enzyme-replacement therapy with recombinant human iduronate-2-sulfatase as a specific treatment for Hunter syndrome is presented. Pediatrics 2009; 124: e1228-e1239″
“Background: Evidence-based quality improvement in nursing homes relies heavily on administrative LY3023414 clinical trial data. Minimum Data Set (MDS) and Online
Survey Certification and Reporting (OSCAR) are the 2 largest sources of national nursing home administrative data. Although clinical measures in each of the data systems have frequently and independently been used to measure nursing home performance, no study has systematically examined their relative reliability.\n\nObjectives: This study estimates the reliability of clinical measures between MDS and OSCAR data and discusses the utility of these databases in research.\n\nResearch Design: We analyzed 4 waves of national MDS and OSCAR data (1999-2002). A comparable group of 24 clinical indicators from both datasets was
selected for the reliability test. Spearman rank-order correlation analyses were used to measure the test-retest reliability relationships.\n\nResults: Across the 4 years, the majority of coefficients of clinical measures exhibit good reliability. There are 17 clinical measures (71% of the total measures) U0126 with correlation coefficients greater than 0.4, the minimally acceptable reliability threshold according to Morris. The highest correlation coefficients were associated with tube feeding at 0.883.\n\nConclusions: Our findings indicate that the target GSK3326595 price clinical measures in OSCAR and MDS arc generally consistent and reliable. However, researchers Should use OSCAR self-reported clinical measures to measure nursing home outcomes in place of corresponding MDS clinical measures with
caution because some indicators in the administrative data are more reliable than others.”
“Aims: The aim of this study was to compare demographics, clinical manifestations, associated systemic and ocular factors, severity and activity of patients with unilateral thyroid eye disease (U-TED) versus bilateral thyroid eye disease (B-TED). Materials and Methods: In a cross-sectional study, all patients with Graves’ hyperthyroidism and primary hypothyroidism seen in an endocrinology clinic were included from September 2003 to July 2006. Demographics, complete eye examination, severity score (NOSPECS, total eye score), and clinical activity score were recorded and compared in the B-TED and U-TED groups of patients. Results: From 851 patients with thyroid disorders, 303 (35.6%) had TED. Thirty-two patients (32/303, 10.56%) were found to have U-TED. Patients with U-TED (mean age 31.6 +/- 11.6 years) were significantly younger than patients with B-TED (mean age 37.7 +/- 14.7 years). Monovariate analysis (Chi-square and independent sample t-test) showed a significantly higher severity score in B-TED (U-TED 4.09 +/- 4.05, B-TED: 6.7 +/- 6.3; P= 0.