The goal of this review was to research if OAB symptoms improved after pelvic surgery for POP. To achieve their goal the authors searched Medline and Embase for studies with the following terms: “overactive bladder” OR “urgency” OR “frequency” OR “nocturia” OR “urge incontinence” OR “micturition,” AND “prolapse” AND “repair” OR

“operation” OR “surgery.” From a total of 328 studies collected, they selected 43 on the basis of the abstract. After studying those in further detail, Inhibitors,research,lifescience,medical the authors identified 12 studies with relevant and analyzable data. Patients with concomitant incontinence surgery were excluded because it was a risk factor for de novo OAB symptoms. In all published studies, the authors found an improvement in the OAB symptoms after pelvic organ surgery. There was no relationship between the compartment of the prolapse, method of surgery, parameter or stage of prolapse, and the results after POP surgery. The results suggested that there is a relationship between OAB and POP. Published materials concurred Inhibitors,research,lifescience,medical that, in the majority of cases, Inhibitors,research,lifescience,medical OAB symptoms improved or disappeared

after POP surgery. The authors noted that the literature review suggests that it is likely that OAB symptoms will resolve after surgery for POP. The Effect of Stress on IC/PBS This interesting animal physiology research was based on the hypothesis that stress appears to play a role in the exacerbation and possibly even the development Inhibitors,research,lifescience,medical of functional urinary tract disorders including OAB and IC/PBS. In patients with IC/PBS, stress may affect quality of life by increasing the symptoms of pain and urgency. Dr. Ariana L. Smith6 and associates

from the University of California Los Angeles, aimed to characterize changes in micturition frequency, interval and anxiety-related Inhibitors,research,lifescience,medical behavior in an animal study to better understand the mechanism underlying this relationship. FTY720 ic50 Twenty-four adult female Wistar rats were subjected to water avoidance, a potent psychologic stressor, or sham, for 1 hour per day for 10 consecutive days. The method included a colonic assessment, a voiding assessment after day 1 (acute stress) and on day 10 (chronic stress), urine norepinephrine levels (days 1 and 10), lightdark box transition test, histologic examination (4 animals from each group), and repeat voiding assessment (the Resveratrol remaining animals underwent voiding assessment every 3 days for 1 month). The authors found that rats exposed to stress developed a significant increase in anxiety-like behavior, voiding frequency and decrease in latency to first void, voiding interval, and volume of first void when compared with sham group animals and with baseline voiding parameters. Alteration in micturition parameters persisted for at least 1 month.