Salkovskis9 offered a cognitive theory of OCD. He proposed that five assumptions are characteristic of OCD: (i) thinking about an action is the same as doing it; (ii) failing to prevent harm is morally equivalent to causing harm; (iii) responsibility for harm is not diminished by extenuating circumstances; (iv) failing to ritualize in response to a thought about harm is the same as an intention to harm; and (v) one should exercise control over one’s thoughts (p 579). Therefore, while the patient may feel their obsessions are unacceptable, the compulsions

used to reduce the anxiety are deemed acceptable. Traditional psychotherapy OCD was initially Inhibitors,research,lifescience,medical viewed as e-book intractable. Psychoanalytic and psychodynamic theories of unconscious drives and wishes produced several formulations of OCD and descriptions of case studies, but did not lead to treatments that reliably

resulted Inhibitors,research,lifescience,medical in significant reduction of OCD symptoms. Nonetheless, due to lack of alternatives, psychodynamic psychotherapy continued to be administered to patients with OCD despite limited clinical benefit.10 Salzman and Thaler11 in their review of the literature concluded Inhibitors,research,lifescience,medical that the traditional approaches to the treatment of OCD “require drastic revision 3-deazaneplanocin A (DZNeP) HCl because they have added nothing to the comprehension or resolution of these disorders.” The authors proposed that treatment should be focused on the here and now, and refrain from using psychodynamic interpretations of past experiences. In his 1983 psychiatric review of OCD, Jenike12 lamented that psychology had little Inhibitors,research,lifescience,medical to offer people suffering from OCD. He noted that “OCD

is generally easy to diagnose but extremely difficult to treat successfully. The abundance of therapeutic approaches available suggests that none is clearly effective in the majority of cases. Psychotherapy and electroconvulsive therapy are ineffective treatments for pure OCD.” 12 At present it is widely recognized that, for OCD, psychodynamic Inhibitors,research,lifescience,medical approaches have little evidence base to justify their use. With regard to psychodynamic therapy and psychoanalysis, one of the most Cilengitide current expert guidelines notes that “there is doubt as to whether it has a place in mental health services for OCD” at all.13 Early behavior therapy Several behavioral interventions were developed to alleviate OCD-related distress, with varying degrees of success. The goal was to reduce obsessional anxiety/distress by exposing the patient to the very events that evoked that distress – and are therefore avoided – until the patient adapted, or habituated, to the situation. Systematic desensitization, developed by Wolpe,14 for phobias, was applied in the treatment of OCD. This approach involved applied relaxation during gradual exposure to feared items and situations. The goal of desensitization was to eliminate the patient’s obsessional anxiety, which in turn was thought to eliminate compulsions or rituals.