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H, Maki Y, Selleckchem TPCA-1 Muraoka T, Shien K, Furukawa M, Ueno T, et al.: Frequent SAHA concentration methylation and oncogenic role of microRNA-34b/c in small-cell lung cancer. Lung Cancer 2012, 76:32–38.PubMedCrossRef 45. Lujambio A, Calin GA, Villanueva A, Ropero S, Sanchez-Cespedes M, Blanco D, Montuenga LM, Rossi S, Nicoloso MS, Faller WJ, et al.: A microRNA DNA methylation signature for human cancer metastasis. Proc Natl Acad Sci U S A 2008, 105:13556–13561.PubMedCentralPubMedCrossRef Competing interests The authors declare that they have no competing interests. Authors’ contributions FL and YZC participated in the design of the study and coordination; XBC and ZMZ wrote Casein kinase 1 the manuscript; XBC, ZMZ,

and WL performed the MALDI -TOF mass spectrometry for miR-34a methylation. TG, YWC, LHW, JFJ and LY performed real-time PCR for quantification of miR-34a expression; DL, TG, SL, and JMH participated in recruitment of patients and collection and assembly of data; CXL, SGL and WHL performed statistical analysis; CYW and LDW helped to draft the manuscript and participated in the design of the study. All authors read and approved the final manuscript.”
“Background Poly (ADP-ribose) polymerase 3 (PARP3) is a novel member of the PARP family, a group of enzymes that synthesize poly (ADP-ribose) on themselves or other acceptor proteins. Recent findings suggest that PARP3 catalyses a post-translational modification of proteins involved in biological processes, such as transcriptional regulation, energy metabolism and cell death [1, 2].