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“Objective. The primary outcome measure of this study was the ability of rHuEPOa therapy to reduce transfusion needs, whereas secondary outcome measures were NICU-LOS and ventilation need.

Methods. All babies with BW < 1250 g and GA < 30 were eligible. Thirty premature neonates were enrolled AG-014699 in vivo in the study (10 treated, 20 controls). rHuEPOa was administered as 300 IU/kg/dose 3 times/week subcutaneously. Iron, folic acid and Vitamin E supplementation were administered

in both groups. Hematologic variables and blood sampling were recorded during the study.

Results. In rHuEPO group, only four (40%) premature infants required a transfusion, averaging 0.4 +/- 0.52 transfusions/pts. A total of 23 transfusions were administered to controls; 11 (55%) infants received

one transfusion at least, 55% required multiple transfusions. The average number of transfusions/pts was statistically different (1.15 +/- 1.46 vs. 0.4 +/- 0.52; p = 0.02), as the cumulative number of transfused patients (55% vs. 40%; p < 0.001). NICU stay was not statistically different, whereas ventilation-free days were increased in EPO group (p < 0.05).

Conclusions. R-Hu-EPO treatment in first post-natal weeks markedly enhanced erythropoiesis in severely premature infants compared with matched controls, with a significant impact on transfusion needs. EPO group experienced also a reduction of ventilation time and, possibly, a decreased occurrence of clinical BPD.”
“Dislocation of the mandibular condyle into the middle cranial fossa is a rare traumatic injury caused by transmission BMS-345541 NF-��B inhibitor of upward force through the condyle onto the glenoid fossa resulting in fracture of the fossa and superior displacement of the condylar head. This type of injury occurs when the “”safety mechanisms” of the mandible fail or are DAPT purchase absent. The authors present the case of a 72-year-old female patient with multiple comorbidities who suffered a subcondylar fracture of the left mandible and dislocation of the right mandibular condyle into the middle cranial fossa after

a fall. Bilateral external fixation of the mandible to the zygomatic arch was utilized to minimize operative time and provide definitive treatment. Many factors must be taken into account when determining the treatment modality for this type of injury, and the final decision should be tailored to each individual case based on several factors including the length of time between injury and presentation, concomitant neurologic deficit, age, and stability of the patient. The goals of treatment are reduction of the dislocation, avoidance of neurologic injury, and restoration of mandibular function. A multidisciplinary effort is necessary to optimize patient care.”
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