Lower HR values were found after five and 30 minutes of recovery compared with the RT session, but not compared with resting values.Table www.selleckchem.com/products/mek162.html 3Cardiovascular responses to an acute resistance training session in the hypertensive women using propanolol (H Group).H group exhibited a lower SBP during set 2 compared with N (Figure 1). No differences in DBP were noted between N and H in any condition (Figure 2). HR and RPP presented lower values for H in all periods as compared with N group (Figures (Figures33 and and4,4, resp.). Figure 1Comparison of systolic blood pressure (SBP) between N (normotense control) and H (hypertensive using propanolol) before, during, and after a resistance exercise session. Mean �� standard deviation of the mean. *Difference between groups (P �� …

Figure 2Comparison of diastolic blood pressure (DBP) between N (normotense control) and H (hypertensive using propanolol) before, during, and after a resistance exercise session. Mean �� standard deviation of the mean. *Difference between groups (P �� …Figure 3Comparison of heart rate (HR) between N (normotensive control) and H (hypertensive using propanolol) before, during, and after a resistance exercise session. Mean �� standard deviation of the mean. Es: effect size. *Difference between groups ( …Figure 4Comparison of rate-product pressure (RPP) between N (normotensive control) and H (hypertensive using propanolol) before, during, and after a resistance exercise session. Mean �� standard deviation of the mean. Es: effect size. *Difference between …5.

Discussion The present study reveals the important clinical role of 40mg/day of propanolol in attenuating the cardiovascular responses to a RT session in mildly hypertensive individuals. In addition, these results have direct implications for RT prescription, highlighting the safety of this type of exercise for mildly hypertensive patients treated with propanolol. During three sets of RT, hypertensive women treated with propanolol exhibited lower values of HR and consequently of RPP compared with normotensive women. Additionally, propanolol modulated cardiovascular variables during resting and in the recovery period of a RT session. This indicates that beta-blockers, such as propanolol, are cardioprotective at rest and during a RT session in hypertensive individuals, who have a higher risk of developing coronary heart disease, cardiac ischemia, and acute myocardial infarction [5].

While the intra-arterial method is considered the gold-standard for determining Brefeldin_A blood pressure [16], we chose to utilize the auscultatory method in the present study. Wiecek et al. [16] found that the indirect (auscultatory) method underestimates pressure values by 15% during sets and by 30% immediately after exercise compared to intra-arterial values. However, the correlation between these methods is significant. In addition, the reliability of the indirect method has been confirmed during moderate/high intensity exercise [17].