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AB carried out the purification of peptides, prepared the samples for CD, NMR and SEM analyses, analyzed the spectra for backbone assignments and secondary structures, performed the experiments on the release of liposome-entrapped calcein and the expression of virulence factors and participated in drafting the manuscript. NV carried out the Bumetanide membrane depolarization studies, the confocal microscopy examinations with fluorescein-labeled pre-elafin/trappin-2 and drafted the manuscript. SM analyzed NMR data and drafted the manuscript. SMG LY411575 datasheet designed and analyzed NMR experiments. YB conceived the study, participated in its design and wrote the manuscript. All the authors have read and approved the final manuscript. The authors declare no competing interest.”
“Background Periodontitis is a chronic destructive infectious disease of the tooth-supporting tissues. It is one of the most prevalent infectious diseases in the world. With percentages of moderate disease ranging from just below 20% in an age group of 30 to 40 year-olds in Swedish and Norwegian studies to even up to 38% of severe cases in the United States in an on average 75 year-old male population [1–3].