Esophageal varices grade 2 or 3 (p = 0.003), refractory ascites (p = 0.01), an increase in the portosystemic gradient (p = 0.008) were significantly more frequently in the TIPS group. Total mortality was not significantly different between the 2 groups. Median follow up was 12 months. Median survival was 26 months (TIPS) vs 27 months (ns). Conclusion: in
this series, TIPS with covered stents for refractory ascites or recurrent bleeding varices restore a survival comparable to a control group with a first decompensation of cirrhosis, without severe portal hypertension Key Word(s): 1. refractory ascites; 2. cirrhosis; 3. covered TIPS; 4. meld score; Presenting Author: WANG DI Additional Authors: GUO XIAO-ZHONG, LI HONG-YU, SHAO XIAO-DONG, CUI ZHONG-MIN, REN LI-NAN, GS-1101 research buy ZHAO JIA-JUN Corresponding
Author: GUO XIAO-ZHONG Affiliations: General Hospital of Shenyang Military Area Command Objective: To evaluate the safety of autologous bone-marrow stern cells mobilization by intravenous injection of granulocyte colony stimulating factor (G-CSF) in patients with decompensated liver cirrhosis patien. Methods: Fifty-one patients with decompensated cirrhosis patients were received intravenous injection of G-CSF (4 μg/kg.d) before treatment Acalabrutinib for 2 days. During the period of treatment, attention was paid to the following side effects bone pain, fever, gastrointestinal effects, and laboratory examination. Results: The incidence of complications during G-CSF treatment was 45.5%, including that of bone pain being of 13.6%, fever being of 27.2%, reinfarction being of 5%. Conclusion: In patients with cirrhosis, intravenous injection of G-CSF to mobilize autologous bone-marrow stem cells is feasible and safe. Key Word(s): 1. liver cirrhosis; 2. Stem cell; 3. Transplantation; 4. G-CSF; Presenting Author: FENG SHI Additional Authors: WENHUA HE, LU CHEN, WEN HUANG, TAO CHEN, DEQIANG HUANG, XUAN ZHU Corresponding Author: XUAN ZHU Affiliations: Telomerase Nanchang University Objective: To observe the effects of ursolic acid (UA) on the expression of NOX
subunit and its regulation on PI3K/Akt and P38MAPK pathways in rat activated hepatic stellate cells (HSCs), and explore the underlying mechanism. Methods: HSC-T6 cells (rat hepatic stellate cells) in the exponential growth phase were divided into six groups: normal control group; leptin (100 ng/ml) treated; leptin treated together with UA (50 μM); leptin treated together with NOX inhibitor DPI (20 μM); leptin treated together with P38MAPK inhibitor SB203580 (10 μM) and leptin treated together with PI3K inhibitor LY294002 (10 μM). HSC-T6 were treated with medicine and the protein expression of NOX subunit gp91phox, p22phox, p67phox, Rac1and PI3K, p-Akt, p-P38MAPK and TIMP-1, MMP-1 were analyzed with Western blotting.