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cofactors. Nature 1997, 385:548–552.CrossRefPubMed 54. MICROCAL ITC Data Analysis in Origin R [http://​www.​microcalorimetry​.​com]Tutorial Guide. 5.0; MicroCal 1998. 55. Batista WL, Matsuo AL, Ganiko L, Barros TF, Veiga TR, Freymüller E, Puccia R: The PbMDJ1 gene belongs to a conserved MDJ1 / LON locus in thermodimorphic pathogenic fungi and encodes a heat shock protein that localizes to both the mitochondria and cell wall of Paracoccidioides brasiliensis. Eukaryot Cell 2006, 5:379–390.CrossRefPubMed 56. Lenzi HL, Pelajo-Machado M, Vale BS, Panasco MS: Microscopia de Varredura Laser Confocal: Princípios e Aplicações Biomédicas. Newslab 1996, 16:62–71. Authors’ contributions BRSN carried out all assays. JFS and MJSMG participated in the adhesion and infection assays. HLL participated in confocal assays. BRSN, MJSMG, HLL, CMAS and MP contributed to the preparation of the manuscript. MP conceived, designed and coordinated the study. All authors

contributed to the discussion of results. All the authors have read and approved the final manuscript.”
“Background check details Bacteria belonging to the genus Acinetobacter, in particular Acinetobacter baumannii and the closely related Acinetobacter 13 TU and gen.sp. 3 (referred to as Acinetobacter baumannii sensu lato), are important opportunistic

Dichloromethane dehalogenase pathogens in hospital-acquired infections (reviewed in [1]). A. baumannii can cause pneumonia, wound infections, urinary tract infections, bacteremia, and meningitis [2, 3]. The hospital environment can represent an important reservoir for A. baumannii during nosocomial infections; in particular, patients in long-term care facilities can be colonized by A. baumannii and carry the bacterium for long periods with no visible symptoms [1]. Ability to persist in the hospital environment is related to multidrug resistance [1, 4], which allows A. baumannii to survive prolonged Selleckchem PD0332991 antimicrobial therapy in hospitalized patients. Multidrug resistance in A. baumannii clinical isolates is mediated by a variety of mechanisms, such as modification of target sites, efflux pumps, enzymatic inactivation of antibiotics, etc. (reviewed in [1]). Carbapenems (e.g. imipenem) have been used as antibiotics of choice for treatment of A. baumannii infections, but increasing resistance to these antimicrobial agents mediated by β-lactamases of the B and D classes is undermining this option [4–8]. In addition to multidrug resistance, A.