Although many of them are benign, a significant percentage are premalignant. Currently, endosonography (EUS) and fine needle aspiration (FNA) makes morphology and cytopathology analysis of cyst fluid for pancreatic

Selleckchem CHIR99021 cystic lesion possible. By these techniques pre- operative differentiation of benign from malignant or potentially malignant pancreatic cystic lesions can be done with 80% accuracy. Methods: In 68 patients with pancreatic cysts, we studied demographic information and the results of EUS imaging, the cystic cytopathology and analysis of cystic fluid amylase and CEA levels. Results: Sixty eight patients were included in the study with an average age of 51 years. Forty six patients were female (68%). Analysis of the lesions were performed based on the cytology findings as well as the other results (CEA, Amylase, cyst morphology, and history of pancreatitis). Patients with pseudo cysts with an average age of 41.4 years, were the youngest of the study population, and those with cystic adenocarcinoma were the oldest with an average age of 61.7 years. the most common types of lesions were 26.5% pseudo cysts (n = 9), 16.2%MCN (n = 11), 14.7% SCA (n = 10), 13.2% IPMN (n = 9)

and 13.2% cystic adenocarcinoma (n = 9). The most common locations of cysts were 35.2% in HKI-272 the head (n = 25). With the exception of the neuroendocrine tumors, all other types of lesions were more Urease common in females than males. The most septations in the cysts were observed in

the cystic adenocarcinomas, SCA, and IPMN. Lesions smaller than 2 cm occurred most frequently in IPMN, while pseudo cysts were all greater than 2 cm. Conclusion: Forty seven percent of patients in this study had malignant or premalignant lesions, who despite being asymptomatic, need routine follow-ups or surgery. Endosonography plays an important role in the diagnosis and treatment of the cystic tumors of the pancreas. Diagnosing premalignant lesions and providing the appropriate treatment increases patient’s survival and the diagnosis of benign cysts, leads to fewer unnecessary surgeries. Key Word(s): 1. serous cystadenoma; Presenting Author: MARC GIOVANNINI Additional Authors: FABRICE CAILLOL, ANNE-ISABELLE LEMAISTRE, BERTRAND PUJOL, BERTRAND NAPOLÉON Corresponding Author: MARC GIOVANNINI Affiliations: Institut Paoli Calmettes; Hôpital privé Jean Mermoz Objective: Needle-based Confocal Laser Endomicroscopy (nCLE) is an imaging technique, which enables microscopic observation of solid organs, in vivo and in real-time, during an EUSFNA procedure.