75 μg HA H1N1/2009 vaccine, two doses of AS03B-adjuvanted 1.9 μg HA H1N1/2009 vaccine and one dose of non-adjuvanted 15 μg HA H1N1/2009 vaccine elicited HI antibody responses that persisted at purported protective levels through 6 months after vaccination and fulfilled the European and US regulatory

criteria. The data from this study are relevant in the context of influenza pandemic preparedness ON-01910 research buy strategies, especially as the study population is likely to be a priority group for vaccination in influenza pandemic scenarios. All authors participated in the implementation of the study including substantial contributions to conception and design, the gathering of the data, or analysis and interpretation of the data. All authors

were involved in the drafting of the article or revising it critically for important intellectual content, and final approval of the manuscript. The study was funded by GlaxoSmithKline Biologicals SA. GlaxoSmithKline Biologicals SA was involved in all stages of the study conduct and analysis (ClinicalTrials.gov Identifier: NCT01035749). GlaxoSmithKline Biologicals SA also paid for all costs associated with the development and the publishing of the present manuscript. All authors had full access to the data. The corresponding author had final responsibility to submit for publication. Dr. Poder has nothing to disclose. Dr. Simurka P has received a consultancy fee from GSK. He has received payments for his role as a member of advisory boards and for consultancy www.selleckchem.com/products/Imatinib-Mesylate.html from GSK, Pfizer and MSD. He has also received payments from GSK and Pfizer for lectures, development of educational presentations, and travel to congresses. Ping Li, Sumita Roy-Ghanta

and David Vaughn are employees of GlaxoSmithKline group of companies and report receiving restricted shares of the company. Arepanrix is a trade mark of GlaxoSmithKline group of companies. The authors are indebted to the participating study volunteers, clinicians, nurses and laboratory technicians at the study sites. We are grateful to the principal investigators including Drs. Margit Narska, Mario Moro, Eva Gojdosova, from the Estonian and Slovakian study sites. To all teams of GlaxoSmithKline Vaccines for their contribution to this study, much especially the clinical and serological laboratory teams, Catena Lauria for clinical study management, Janice Beck for preparation of the study protocol and related study documentation. Finally, we thank Avishek Pal (GlaxoSmithKline Vaccines) and Adriana Rusu (XPE Pharma and Science) who provided medical writing services and Santosh Mysore and Shirin Khalili (XPE Pharma and Science, c/o GlaxoSmithKline Vaccines) for editorial assistance and manuscript coordination. “
“Vaccine development has a proud history as one of the most successful public health interventions to date. Vaccine development is historically based on Louis Pasteur’s “isolate, inactivate, inject” paradigm.