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“Brentuximab vedotin is an antibody drug conjugate recently approved for www.selleckchem.com/products/Romidepsin-FK228.html the treatment of adult patients with relapsed or refractory Hodgkin lymphoma. Here, we present a patient with brentuximab vedotin-associated pancreatitis diagnosed on the basis of clinical and radiologic findings and laboratory data. To our knowledge there have been no published reports of pancreatitis Tacrolimus (FK506) occurring with this medication.
A 65 year old white man was diagnosed in December 2011 with Hodgkin lymphoma, mixed cellularity subtype, stage IIa, non-bulky disease involving abdominal sites, without retroperitoneal lymph node involvement. The patient denied a personal or family history of gastrointestinal disease, smoking, or alcohol abuse and was not obese. From January to July 2012, the patient received six standard cycles of adriamycin, bleomycin, vinblastine, and dacarbazine treatment and, because of lymphoma refractoriness, from November to January 2013 four cycles of ifosfamide, gemcitabine, vinorelbine, and prednisone salvage therapy, without experiencing any gastrointestinal disorder. Unfortunately, post-chemotherapy computed tomography, positron emission tomography, and inguinal lymph node biopsy showed disease progression. Therefore, on April 2013, the patient began treatment with 1.8 mg/kg brentuximab vedotin total dose 150 mg, intravenously once every 3 weeks. The patient did not receive premedication. Laboratory tests after the first administration showed an increase in aspartate aminotransferase, alanine aminotransferase, and gamma glutamyl transferase levels that normalized click here within a few days. A few days after the second brentuximab vedotin infusion, the patient developed nausea, stypsis, and epigastric pain.