001) Gleason grade at a positive margin was 3 and 4/5 in 154 (74

001). Gleason grade at a positive margin was 3 and 4/5 in 154 (74%) and 53 patients (26%), respectively. The latter group was significantly

more likely to progress (p<0.001). The overall margin status concordance index was 0.636. It was not considerably enhanced by categorizing by positive surgical margin linear length/highest Gleason grade at positive margins.

Conclusions: The linear extent of and highest Gleason grade at a positive surgical margin are associated with progression. However, subcategorization does not importantly Cediranib in vitro add to predictive models using margin status only. More robust markers are needed in patients with positive surgical margins to warrant routine reporting and identify those at risk for biochemical recurrence.”
“Although the literature on hallucinations in psychiatric patients shows clear links with anxiety and depression, associations of affect with a wider array of anomalous perceptual experiences have been much less studied. This study investigated patients with psychosis (N = 29) and a non-clinical population (N = 193) using the Cardiff Anomalous Perceptions Scale (CAPS), a measure of perceptual distortion and associated distress, intrusiveness

and frequency; along with measures of depression, anxiety and worry. The study also allowed a re-validation of the CAPS in a more representative sample of the UK population. Moderate, reliable correlations with depression, anxiety and worry were found selleck screening library in the non-clinical population with the association being stronger in psychotic patients. The study re-confirmed that anomalous

perceptual experiences are common in the general population and that a significant minority (11.9%) have higher levels than the mean of psychotic patients. Scale reliability and validity were also re-confirmed, and the CAPS AZD5582 score was found to be unrelated to age or gender in either sample. As in the original study, factor analysis produced a three-factor solution, although factor theme was not fully replicated: as before, a cluster of first-rank symptoms emerged, but with equivocal evidence for a temporal lobe factor and no replication of a ‘chemosensation’ component. Crown Copyright (C) 2011 Published by Elsevier Ltd. All rights reserved.”
“Purpose: We examined the performance of C-11-choline positron emission tomography/computerized tomography for its ability to delineate prostate cancer distribution and extent after initial therapy.

Materials and Methods: A consecutive series retrospective review was performed of all patients with prostate cancer who were evaluated using C-11-choline positron emission tomography/computerized tomography from September 2007 to November 2010 at the Mayo Clinic.

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