ρ, Spearman’s rank correlation coefficient. Although the analysed parameters were not normally distributed, if the Pearson correlation test was free copy used, CRP showed significant correlations with MPV/PC (r=0.164, p<0.001), NLR (r=0.517, p<0.001) and ESR (r=0.479, p<0.001) in patients with cerebral infarction. However, there was not a significant correlation between CRP and MPV (r=0.068, p=0.121) in patients with cerebral infarction. Also, these similar results were noted in male (n=291) or female (n=225) divided group analysis. In the male group, CRP showed significant correlations with MPV/PC (r=0.144, p=0.014), NLR (r=0.413, p<0.001)

and ESR (r=0.82, p<0.001) in patients with cerebral infarction. In the female group, CRP showed significant correlations with MPV/PC (r=0.197, p=0.003), NLR (r=0.620, p<0.001) and ESR (r=0.484, p<0.001) in patients with cerebral infarction. Discussion There were many factors of cerebral infarction pathogenesis. We thought activated platelets could be produced in various cerebral vascular diseases and these conditions might increase MPV. The inflammation seems to be related with the pathogenesis of cerebral infarction. Inflammation is found to develop at a sufficiently early stage

in progressive ischaemic brain injury.16 Besides cerebral infarction, our previous study showed a positive correlation of CRP with MPV/PC and NLR were noted in patients with pneumonia.17 Recently, there were various studies that dealt with relationships between haematological indices and cerebral infarction.18–20 Arikanoglu et al18 reported

that CRP and MPV are higher in the patients with ischaemic stroke who died in comparison to those who survived. MPV is a novel index for silent cerebral infarction regardless of classical cardiovascular risk factors.19 Also, NLR predicts poor prognosis in ischaemic cerebrovascular disease.20 Although CRP level and outcome of ischaemic stroke is under debate,21 the inflammation might be related to a certain progression of cerebral Brefeldin_A infarction. Therefore, CRP is a representative inflammatory marker, and appears useful in comparing new parameters with CRP in patients with cerebral infarction. For the first time, this study showed MPV and NLR as expected ESR could be statistically correlated with CRP in a moderate number of patients with cerebral infarction. We identified that MPV was correlated with CRP overall and in the female group, but was not correlated in the male group. A report suggested that in Korea, women had a higher median PC than men.22 A few studies suggested that men had slightly higher MPV than women.23 24 Only female MPV showed significant correlation with CRP. The exact causes of gender difference were not uncovered, but it might owe to a difference of PC or hormonal differences between women and men.