Can you run or ride a bike uphill? Can you run for 6 or 7 min (about 800 m)? Can you go up stairs for a distance of two floors? >10 METs (degree of activity: excellent) If the patient can participate in activities such as swimming, soccer, or skiing, the daily activity score is “> 10

METs” As with coronary MM-102 mouse artery VX-680 datasheet disease, heart failure is commonly associated with hip fracture. It has recently been shown in a cohort of 5,613 persons from the Cardiovascular Health Study with average follow-up of 11.5 years that patients with heart failure have a much higher incidence of hip fracture compared with those without SB431542 solubility dmso heart failure (14/1,000 vs. 6.8/1,000

person-years). More importantly, patients with both heart failure and hip fracture have a twofold increase in risk of death compared with those with heart failure alone [13]. Patients with heart failure who undergo non-cardiac surgery have a poorer outcome than those without heart failure [14]. It is thus essential to identify patients with heart failure and optimize their cardiac condition prior to surgery. In addition, the presence of significant valvular disease, in particular, severe aortic stenosis, confers a substantial risk of perioperative cardiac events in patients who undergo non-cardiac surgery [11, 15–17]. Aortic stenosis is relatively common in geriatric patients (>65 years) [18, 19] and is often associated

with hip fracture. In a retrospective study that included 3,997 consecutive patients with a hip fracture, 272 (6.8%) were confirmed MRIP to have a previously undiagnosed aortic stenosis as a result of echocardiography to investigate a previously undiagnosed heart murmur [20]. While it is recommended that echocardiography should be performed as part of a preoperative assessment if aortic stenosis is suspected, to allow confirmation of diagnosis, risk stratification, and possible cardiac intervention [21], the clinical decision on whether to operate on such patients remains a challenge due to the scarcity of clinical outcome data. In a retrospective study by Adunsky and colleagues involving 56 patients with hip fracture and aortic stenosis (mean valve area 0.97 ± 0.