Cummings SR, Eckert S, Krueger KA, Grady D, Powles TJ, Cauley JA, Norton L, Nickelsen T, Bjarnason NH, Morrow M, Lippman ME, Black D, Glusman JE, Costa A, Jordan VC (1999) The effect of raloxifene on risk of breast cancer in postmenopausal women: results
from the MORE randomized trial. Multiple Outcomes of Raloxifene Evaluation. JAMA 281:2189–2197CrossRefPubMed 14. Vickers MR, MacLennan AH, Lawton B, Ford D, Martin J, Meredith SK, DeStavola BL, Rose S, Dowell A, Wilkes HC, Darbyshire JH, Meade TW (2007) Main morbidities recorded in the women’s international study of long duration oestrogen after menopause (WISDOM): a randomised controlled trial of hormone replacement therapy in postmenopausal women. BMJ 335:239CrossRefPubMed 15. Barrett-Connor E, Mosca L, Collins P, Geiger MJ, Grady D, Kornitzer M, McNabb MA, Wenger NK (2006) Effects of raloxifene on cardiovascular events and learn more breast cancer in postmenopausal women. N Engl J Med 355:125–137CrossRefPubMed 16. Jick H, Jick SS, Derby LE (1991) Validation of information recorded on general practitioner based computerised data resource in the United Kingdom. BMJ 302:766–768CrossRefPubMed 17. Jick SS, Kaye JA, Vasilakis-Scaramozza C, Garcia Rodriguez LA, Ruigomez FK506 clinical trial A, Meier CR, Schlienger RG, Black C, Jick H (2003) Validity of the general practice research database. Pharmacotherapy
23:686–689CrossRefPubMed 18. Lawrenson R, Todd JC, Leydon GM, Williams TJ, Farmer RD (2000) Validation of the diagnosis of venous thromboembolism in general practice database studies. Br J Clin Pharmacol 49:591–596CrossRefPubMed 19. Ray WA (2003) Evaluating medication effects outside of clinical trials: new user designs. Am J Epidemiol 158:915–920CrossRefPubMed 20. Grosso A, Douglas I, Hingorani A, MacAllister R, Smeeth L (2008) Post-marketing assessment of the safety of strontium ranelate: a novel case-only approach
to the early detection of adverse drug reactions. Br J Clin Pharmacol 66:689–694PubMed 21. Farrington CP (2004) Control without separate controls: evaluation of vaccine safety using case-only methods. Vaccine 22:2064–2070CrossRefPubMed next 22. Decensi A, Maisonneuve P, Rotmensz N, Bettega D, Costa A, Sacchini V, Salvioni A, Travaglini R, Oliviero P, D’Aiuto G, Gulisano M, Gucciardo G, del Turco MR, Pizzichetta MA, Conforti S, Bonanni B, Boyle P, Veronesi U (2005) Effect of tamoxifen on venous thromboembolic events in a breast cancer prevention trial. Circulation 111:650–656CrossRefPubMed 23. Heit JA, Silverstein MD, Mohr DN, Petterson TM, Lohse CM, O’Fallon WM, Melton LJ III (2001) The epidemiology of venous thromboembolism in the community. Thromb Haemost 86:452–463PubMed 24. Scottish Intercollegiate Guidelines Network (2002) Prophylaxis of Venous Thromboembolism: a national clinical guideline. SIGN, Edinburgh 25.