Results: The mean GBS was 8.87+3.20 in our cohort. The GBS had a moderate correlation with the Forrest classification of the ulcer identified during index endoscopy (R = -0.387, p < 0.001). Two hundred fifteen (80.8%) of the 266 patients with low-risk GBS had ulcers with a low-risk SRH, while 111 (38.9%) of the 285 patients with high-risk GBS had ulcers with high-risk SRH (p < 0.001). A high-risk GBS has a positive predictive value (PPV) of 31.38% and a negative predictive value (NPV) 88.89%. Epigenetics Compound Library ic50 A low-risk GBS has a PPV of 12.33% and a NPV of 96.2%. On logistic regression models, a low-risk GBS was predictive of a low-risk SRH (OR 2.69, 95%CI

[1.82–3.96], p < 0.001). Conclusion: The GBS is significantly correlated with the Forrest class of the bleeding lesion found during upper endoscopy of patients with NVUGIB. This study underlines the importance of determining the GBS at presentation of patients with NVUGIB as a low GBS can identify patients with low-risk SRH. Key Word(s): 1. UGIB; 2. Blatchford Score; 3. Forrest Class; 4. SRH; Presenting Author: IVANA TIRIC Additional Authors: MATKO MARKOTIC,

HRVOJE IVEKOVIC, MASA CAVLINA, PAVE MARKOS, KATJA GRUBELIC RAVIC, MILORAD OPACIC, NADAN RUSTEMOVIC Corresponding Author: IVANA TIRIC Affiliations: General Hospital Dr. Tomislav Bardek; AZD1208 price General Hospital Virovitica; University Hospital Centre Zagreb Objective: Identification of the ethiology, clinical features and outcomes in the octogenarians with upper gastrointestinal bleeding, and comparison with the younger patients. Methods: Patients who had presented with upper gastrointestinal bleeding, and managed at three hospitals in Croatia, during the period 2010–2012, were reviewed. The patients were divided into two groups: older than 80 years and younger. Differences between two groups were egzamined by χ2 test. Results: Of 913 patients included, 19.2% were octogenarians. Compared to the younger patients, less octogenarians were men (506 (68,7%) vs 75 (42,6%), p < 0,001),

alcohol consumers (196 (27,6) vs 11 (6,4), p < 0,001) and smokers (164 (23,2) vs 5 (2,9), p < 0,001), there was lower percentage medchemexpress of patients with liver cirrhosis (116 (15,9) vs 8 (4,6), p < 0,001), and higher percentage of those with accompanying cardiovascular nad renal disease (51 (7,0) vs 27 (15,4), p = 0,001 and 240 (33) vs 117 (66,9), p < 0,001). Higher intake of acetylsalicylic acid and anticoagulant drugs was registered in those over 80 (111 (15,1) vs 51 (29,0), p < 0,001 and 66 (9,0) vs 34 (19.3), p < 0,001). According to the laboratory findings, octogenarians had significantly higher urea and creatinin values (11,8 (9,2) vs 17,1 (12,8), p < 0,001 and 117 (94,3) vs 158 (125,2), p < 0,001).