The majority of local and systemic reactions

were mild and transient. There were no SAEs deemed to be related to vaccine. Results from this study add further support to the overall safety study profile of LJEV when given alone or with measles vaccine. At their June 2013 meeting, the Global Advisory Committee on Vaccine Safety, convened by WHO, reviewed updated safety information on the LJEV, including from this study, and concluded that the LJEV has an “excellent” safety profile [17]. Many new JE vaccines have emerged on the global market in the past 5 years. The comparative advantages of LJEV for routine use in public sector markets include its single dose schedule, affordable price, and demonstrated effectiveness. Studies in China have shown protective efficacy of 96–98% up to 17 years after a two-dose regimen [18]. A study from Nepal also reported protection of 99.6% after a single dose given within one week of an outbreak [19], and follow-up studies in that population http://www.selleckchem.com/products/ve-821.html have demonstrated continued high protection (98.5%) 12–15 months after vaccination

[20] and 5 years after vaccination (96.2%) [21]. A recent study in Nepal after mass campaigns with LJEV further demonstrates the vaccine’s impact on substantially reducing laboratory-confirmed JE and acute encephalitis syndrome cases [22]. In addition to Sri Lanka, 10 other Asian countries have national or subnational JE vaccine programs, of which China, India, Nepal and Cambodia also crotamiton utilize the LJEV vaccine [2]. In October of 2013, the WHO prequalified LJEV for procurement by United Nations agencies, and in November 2013, the GAVI Alliance opened EGFR inhibitor a window of funding for Japanese encephalitis vaccine that will allow countries to submit proposals for financial support of JE vaccine campaigns. These historic decisions provide the Libraries opportunity to further the use of JE vaccine across Asia and the Pacific and provide protection to all children at risk of this devastating disease. This study, under PATH protocol JEV03/04, was designed, managed, conducted, and analyzed by PATH in collaboration with the investigators

and under the supervision of the Sri Lanka Ministry of Healthcare and Nutrition. The authors acknowledge the volunteers and their families because without their participation this research would not have been possible. At the Ministry Of Healthcare and Nutrition, we acknowledge Dr. S. Dissanayake, Dr. S. Kariyawasam, and Dr. R. Batuwanthudawe. In the District of Colombo, we thank Medical Officers of Health, Dr. S.D. Abeysinghe, Dr. W.B.R. Gunawardena, Dr. M.M.J. Dharmadasa, and Dr. W.P.S. Gunarathna, as well as Dr. I. Pinnaduwa and N. Pannilahetti. We also thank physician research assistants, G.N. Dahanayake, V.S. Dharmakulasinghe, P.R.N. Jayakody, W.A. Karunarathna, S.K. Mahanama, T.D. Perera, I.A. Samarasekara, and C. de Silva, and public health nursing sisters, J.M.A. Chandrasili, M.G.S. Epa, W.A.C. Jayasooriya, G.A.B. Mulin, S.K. Nanayakkara, H.A.J.