The medical information of 43 recently diagnosed MM patients Intrapartum antibiotic prophylaxis from January 2014 to January 2019 were examined retrospectively. Immunoturbidimetry was used to detect the expression levels of sFLC κ and λ. In line with the ratio of involved and uninvolved sFLC, using 100 as a boundary, the MM patients were divided into the large proportion group (sFLCR≥100 or ≤0.01) and the reasonable proportion team (0.01<sFLCR<100). The medical signs, the curative impact after 4 courses of induction treatment, together with survival period of the two groups were compared. And in accordance with whether the sFLCR ended up being regular following the 4 courses of induction therapy, the MM patients were divided into regular and unusual sFLCR teams. The survival time of the two teams had been contrasted. Peripheral bloodstream types of 50 recently identified MM patients managed in our hospital from July 2018 to November 2019 and 34 healthy persons underuent real at exactly the same time had been gathered. PCT caused by collagen/epinephrine (CEPI) and collagen/adenosinediphosphate (CADP) in peripheral bloodstream were detected by PFA-200，and the clinical information included age, sex, leukocyte count, hemoglobin degree, platelet matter and standard of serum creatinine, cystatin c, blood calcium, β -MG), bone marrow plasma cells, light sequence protein, as well as the MM kinds, ISS phase of clients were collected. The degree of PCT in MM clients had been substantially greater than that in healthy persons; the amount of PCT were significantly increased with all the increasing of ISS stage in newly identified MM patients; After chemotherapy with bortezomib/dexamethasone (BD), the amount of PCT in 15 patients who have been responded to the therapy ended up being notably lower than those before treatment. The platelet closing time is abnormal in MM customers, moreover, pertains to the progress associated with infection. It’s an essential medical relevance for the analysis of diagnostic phase and healing effectiveness evaluation of MM customers.The platelet closing time is unusual in MM patients, moreover, pertains to the progress of the infection. This has an important clinical importance for the assessment of diagnostic phase and healing efficacy evaluation of MM clients. Que of various focus could inhibit mobile proliferation with time and dose centered manner. The circulation cytometry revealed that Que could notably increase the cell apoptosis and arrest NCI-H929 cells within the G The appearance of VCAN, FK and FN in the efficient team after therapy had been somewhat lower than that before treatment (P＜0.05), nonetheless, the expression of MK and HAS showed no statistically considerably different before and after therapy (P＜0.05). The expression of VCAN of patients in non remission team ended up being dramatically more than that in control group (P＜0.05). The expression of FAK and FN of patients in no remission team was considerable increased as compared because of the customers in recently diagnosed group (P＜0.05). The relative expression of VCAN mRNA in the patients at 3rd phase was notably higher than those during the 1st stage (P＜0.05) and control group but revealed no factor to your patients at second stage (P＜0.05). The phrase of VCAN as well as its related proteins (FAK, MK, FN) revealed favorably correlation in bone marrow mononuclear cells of MM clients (P＜0.05). The correlation between VCAN and HAS wasn’t statistically significant (r=0.259，P＞0.05). Survival evaluation showed that the general appearance of VCAN mRNA was associated with OS (P=0.049) and PFS (P=0.041) in MM clients. The ethnical information from 186 newly diagnosed MM patients hospitalized within the division of Hematology of Harrison Global Peace hospital from January 2012 to January 2019 were analyzed retrospectively. The fluorescent in situ hybridization (FISH) and G-binding staining were used to identify cytogenetic abnormalities (P53 deletion, lq21 amplification and IgH rearranagement) for analyses of total remission (CR), overall reaction price (ORR), progression-free survival (PFS) and overall survival (OS) of patients addressed with bortezomib for 4 groups. In 186 patients, simple P53 deletion was 14 cases, 1q21 amplification and P53 deletion were present in 11 cases (an organization), t (14;16) and P53 deletion in 7 cases (B team), t (4;14) and P53 removal in 9 cases (C team). The whole remission rate (CR%) of above-mentioned three teams had been 27.27%, 28.57% and 33.33% correspondingly, while the ORR for the three groups had been 54.54%, 57.14% and 55.56%, correspondingly, there is no statistically significant distinction between the 3 teams (P＞0.05). The clients with 1q21 amplification and P53 deletion had reduced OS and PFS time (P=0.041, P=0.046). The double-hit patients with 1q21 amplification revealed smaller OS time, weighed against the patients with P53 removal (P=0.027). The double-hit customers with t(14;16) and t(4;14) revealed smaller OS time (P=0.871, P=0.276) and PFS time (P=0.955, P=0.379) than those of the patients with P53 removal. The bone marrow liquid of 40 recently identified several myeloma patients with no treatment and 30 control individuals with fairly normal bone tissue marrow had been gathered. Flow cytometry had been accustomed separated the conventional and abnormal plasma cells, LV-Blimp1-RNAi (40051-2) recombinant lentivirus down-regulates the appearance of Blimp-1 in U266 mobile line and detected the modifications of the expression of ATF4 and CHOP gene. U266 cells had been stimulated by aspirin at different concentrations (0, 0.5, 2.5, 5.0 mmol/L) in vitro. Then your effectation of aspirin on expansion of U266 cells had been calculated by CCK-8 assay, the mRNA expression quantities of Blimp1, ATF4 and CHOP in four teams had been detected by real-time PCR.