Quantitative fiber tracking combined with assessment of cognitive and motor functions enabled the identification of

selective brain structure-function relations in healthy adults without lesions that were previously observed only in patients with lesions of the internal capsule. (C) 2010 Elsevier Ltd. All rights reserved.”
“Whereas patients with schizophrenia exhibit early visual processing impairments, their capacity at integrating visual information at various spatial scales, from low click here to high spatial frequencies, remains untested. This question is particularly acute given that, in ecological conditions of viewing, spatial frequency bands are naturally integrated to form a coherent percept.

Here, 19 patients with schizophrenia and 16 healthy controls performed a rapid emotion

recognition task with hybrid faces. Because these stimuli displayed in a single image two different facial expressions, in low (LSF) and high (HSF) spatial frequencies, the selected emotion probes which spatial MG-132 in vivo scale is preferentially perceived. In a control experiment participants performed the same task with either low or high spatial frequency filtered faces.

Results show that patients have a strong bias towards LSF with hybrid faces compared to healthy controls. However, both patients and healthy controls performed better with HSF filtered faces than with LSF filtered faces in the control experiment, demonstrating that the bias found

with hybrid stimuli in patients was not due to an inability to process HSF.

Whereas previous works found a BF contrast deficit in schizophrenia, our results suggest a deficit in the normal time course of concurrently perceiving LSF and HSF. This early visual processing impairment is likely to contribute CH5424802 cell line to the difficulties of patients with schizophrenia with facial processing and therefore social interaction. (C) 2010 Elsevier Ltd. All rights reserved.”
“Motor control strongly relies on neural processes that predict the sensory consequences of self-generated actions. Previous research has demonstrated deficits in such sensory-predictive processes in schizophrenic patients and these low-level deficits are thought to contribute to the emergence of delusions of control. Here, we examined the extent to which individual differences in sensory prediction are associated with a tendency towards delusional ideation in healthy participants. We used a force-matching task to quantify sensory-predictive processes, and administered questionnaires to assess schizotypy and delusion-like thinking. Individuals with higher levels of delusional ideation showed more accurate force matching suggesting that such thinking is associated with a reduced tendency to predict and attenuate the sensory consequences of self-generated actions.